Formulation and Evaluation of Paracetamol Tablet Using Konjac Glucomannan as Natural Halal Binder

Introduction: Discovery and development of novel halal excipients in tablet formulation have led to continuous interest in drug delivery research. In this study, Konjac Glucomannan, a polysaccharide derived from the tuber of Amorphophallus konjac, was used as a halal binder in the formulation of paracetamol tablets.

Objective: This study aims to formulate and evaluate paracetamol tablets using konjac glucomannan as a halal binder.

Methodology: Paracetamol tablets were formulated with different concentrations (5%, 10%, 15%, 20%) of KGM using the wet granulation method. The formulated paracetamol granules and tablets were subjected to different quality control tests.

Results: All four formulation granules passed the pre-compression test, indicating good to passable powder flowability. The weight variation, hardness, thickness, and disintegration test results for all four formulations were within the USP limit except for the friability test. Only tablets with 20% KGM passed the test.

Conclusion: 20% KGM shows good tablet binding properties compared to 5%, 10%, and 15% KGM. Hence, paracetamol tablets formulated with higher KGM as a binder produce paracetamol tablets with good physical and mechanical properties.