The impact of Vitamin D replacement on Glucose Metabolism

Objective: We investigated the impact of vitamin D supplementation on glucose metabolism in Vitamin D-deficient patients with prediabetes.

Methods: A total of 66 subjects with the mean ages 52.2±9.9 years were included in this prospective and a 6-month follow-up study between 2008-2010. Vitamin D deficient patients ( < 25ng/ml) were supplemented with oral Vitamin D.

Results: Vitamin D deficiency ( < 25ng/ml) was found in 93.9% of the patients. Post replacement Vitamin D levels increased significantly and insulin, HbA1c, and HOMA-IR decreased significantly following Vitamin D replacement.

Conclusion: We found Vitamin D deficiency was very common in our study population. In Vitamin D deficient patients, supplementation treatment improved insulin resistance and glycemic parameters. Vitamin D replacement may be a promising intervention for the primary prevention of insulin resistance syndromes.