In vitro Comparison of Metronidazole and Tinidazole Activity against Trichomonas vaginalis Strains in Maiduguri, Nigeria

This study investigated the in vitro comparison of metronidazole and tinidazole activity against Trichomonas vaginalis strains from internally displaced women in Maiduguri, Nigeria. Materials and Methodology: high vaginal swab samples were collected from (41) T. vaginalis positive women who consented for the study was cultured and isolated. The results were analyzed using SPSS statistics version 20.0. Results recorded (53) T. vaginalis strains for metronidazole with minimum inhibitory concentration (MIC) range from 0.4 - 25 μg/ml and low-level resistance strains to metronidazole observed 3.8% at 25.0 μg/ml with minimum latent concentration (MLC) ≥ 50.0 μg/ml. Forty-nine (49) T. vaginalis strains were observed on the MIC range from 0.4 µg/ml to 12.5 µg/ml, indicating that all strain isolates were susceptible to tinidazole at above 12.5 μg/ml MLC. This study showed in vitro low resistance to metronidazole in a few T. vaginalis strains, while all the tested isolates were sensitive to tinidazole.