Pillai, Pooja and D, Jhoshitha and A, Joshitha and G, Summana Sree and Devi, Akoijam Charulata and Tejasree, Dadam and Siddique, Shifa Raihaan (2024) Unraveling Human Chimerism: Contemporary Perspective on Embryonic Development by Cellular Fusion and Artificial Methods. PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY, 25 (3-4). pp. 43-53. ISSN 0972-2025
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Abstract
Chimerism, a fascinating biological occurrence, occurs when an organism possesses cells from two or more individuals, often stemming from the death of a fraternal twin. This phenomenon plays a role in stem cell biology, where pluripotent stem cells combine with embryos, influencing cancerous cell development. Human chimerism is observed in 5–15% of people, and artificial chimeras are created in stem cell research for organ development studies. Macrochimeras, with a hermaphrodite phenotype, are associated with sexuality and transgender identity. Tetragametic chimerism involves an unknown fraternal twin inside an individual, resulting in a unique mix of sexes. Research on chimerism in transplantation models contributes to regenerative medicine and disease-resistant crops, albeit with ethical concerns. In summary, chimerism is significant for understanding development, studying diseases, and advancing regenerative medicine, despite ethical considerations.
Item Type: | Article |
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Subjects: | STM Open Academic > Biological Science |
Depositing User: | Unnamed user with email admin@eprint.stmopenacademic.com |
Date Deposited: | 20 Apr 2024 08:10 |
Last Modified: | 20 Apr 2024 08:10 |
URI: | http://publish.sub7journal.com/id/eprint/2126 |