Ameliorating Effect of Moringa against Liver and Kidney Injury Induced by Monosodium Glutamate: Brief Overview

Background: Monosodium glutamate (MSG) produces adverse and damaging effects in different
organs like liver and kidneys. Moringa has ameliorating effect on kidney and liver injury induced by
monosodium glutamate.
Objective: To study the ameliorating effect of moringa against rats liver and kidney injury induced by
monosodium glutamate.
Design: Prospective study.
Setting: College of Pharmacy, Qassim University.
Materials and Methods: This study was performed on 20 male rats and equally divided into 4
groups. The first group was control group, second group was moringa group, third group was MSG
group and forth group was MSG plus moringa group. We determined liver function, albumin, total
protein, kidney function, electrolytes and histopathological examination of tissue.
Main Outcome Results: Moringa has ameliorating effect on kidney and liver injury induced by
monosodium glutamate.
Sample Size: A total of 20 malerats.
Results: There was a significant increase in the levels of serum aspartate transaminase (AST) and
alanine transaminase (ALT), alkaline phosphatase (ALP), urea and creatinine. Significant decrease in
the levels of albumin, total proteins and sodium levels in rats treated with monosodium glutamate.
Kidney sections revealed normal structure of glomeruli and renal tubules as control group, liver
revealed good improvements and mild cellular infiltrations were observed in rats treated with MSG
and moringa group.
Conclusion: Moringa causes ameliorating effect on kidney and liver injury induced by monosodium
glutamate in rats.
Limitation of the Study: Few studies about the protective effect of Moringa against toxic effect of
MSG. So we need to focus on its beneficial effect against toxicity induced by MSG.