Synthesis and Characterization of N-((tetrazol-5 yl)methyl)cyclohexanamine through 2D NMR Experiments: An Overview

Tetrazoles are an important class of nitrogen containing heterocycles with a wide range of medicinal
and commercial applications. Tetrazolyl analogs of amino acids exhibit versatile biologic activity, and
some of them are known pharmaceuticals. In addition, compounds of this type may be using in
development of radiopharmaceuticals for positron emission tomography.
In continuation of our investigations in the tetrazolic amino acids, we described in this presentation the
synthesis and characterization of some aminoalkyl and tetrazolic amino acid derivatives basing on
different spectroscopic methods as NMR 2D.
A simple synthetic approach to N-((tetrazol-5-yl)methyl)cyclohexanamine in two steps starting from
chloroacetonitrile and cyclohexylamine is reported. The synthesized compound was characterized by
2D NMR spectroscopy (1H, 13C) and elemental analysis data.