Investigation on Potentiality of 2h-Furo [2,3-H]-1-Benzopyran-2-One from Psoralea corylifolia L. Seeds against Gram Negative Human Bacteria

Antibacterial activity of the bioactive compound 2H-Furo[2,3-H]-1-benzopyran-2-one against five human bacterial species viz., Klebsiella pneumonia, Vibrio cholera, Escherichia coli, Shigella dysenteriae and Salmonella typhi were tested at 100-1000ppm concentration. Among the five bacterial species tested, K. pneumonia recorded 32.0mm inhibition at 700mm concentration (MIC 700ppm). V. cholera showed 25.0mm inhibition at 600ppm concentration(MIC 600ppm), E. coli recorded 30.0mm inhibition at 900ppm concentration(MIC 900ppm), S. dysenteriae recorded 30.0mm in 600ppm concentration(MIC 600ppm. S. typhi recorded 30.0mm inhibition at 800ppm concentration(MIC 800ppm). All the result was compared to standard synthetic antibiotics Gentamycin and Tetracycline at 25mg concentration. From the observation made, a further investigation is needed to isolate other bioactive compounds for different biological assays.