A Case Series on Neuroendocrine Carcinoma of Esophagus

Neuroendocrine neoplasms (NENs) are a heterogeneous group of neoplasms with neuroendocrine phenotype. They range from well differentiated neuroendocrine tumors (NETs) to aggressive poorly differentiated neuroendocrine carcinomas (NECs). Esophageal neuroendocrine carcinomas (NECs) are rare and aggressive type of esophageal carcinoma with positive neuroendocrine immunohistochemical markers and usually involve lower esophagus. The esophageal NECs present most commonly with gastrointestinal symptoms such as dysphagia and/or abdominal discomfort. They have the potential for distant metastasis. The present case series delineate the recent classification of neuroendocrine neoplasm of esophagus. All the patients present with symptoms of dysphagia and ulcerative growth pattern with positive neuroendocrine immunohistochemical markers.