Gray Zone Patients in Our Clinical Data: Prospective and Retrospective Analyses

Objective: To determine the relationship between the prostate volume and the serum values of prostate specific antigen (PSA)among patients in the “grey zone, “classified according to their age group.

Material and Methods: Prospective and retrospective 1420 patients classified in four age-groups with LUTS were analyzed. Patients were treated for Benign prostate hyperplasia (BPH) in the urology clinical at the University Clinical Center of Kosovo during the period of January 2010 - October 2014. Data were recorded from patients according to age, prostate size estimated by trans abdominal ultrasound using 3.5MHz ultrasonography, according to the ellipsoid formula, V = D1xD2xD3/2.5, volume of prostate, V=T x AP x CC x Pi /6 where T = transverse diameter, AP = antero -posterior diameter, CC = cranial caudal diameter. Patients with confirmed prostate cancer were excluded from the study. Statistical analyses used t-test and ANOVA with 95 and 99% confidence intervals.

Results: For the “grey zone” patients, these mean values were 44.6 cm3 and 5.9 ng/mL.

Conclusions: PSA is strongly correlated with prostate volume and age in patients with BPH. The data provide evidence to support that prostate volume and serum PSA concentration significantly correlate with aging and within the “grey zone” patients.