2-Amino-N-(Substituted Alkyl) Benzoxazole-5- Carboxamide Derivatives as Antiinflammatory and Antioxidant Drugs

The objective of the Present work is to synthesize, characterization and Pharmacological evaluation of 2-Amino-N-(substituted alkyl) benzoxazole-5- carboxamides for anti-inflammatory and antioxidant activities starting from 4-carbomethoxynitrophenol. Evaluation of the compounds showed Vc(R=ethyl), Ve(R=propyl) and Vg (R=diisopropyl) V g (R=propyl) as the most powerful ones. When compared to the standard ascorbic acid, compound Vf (R=isopropyl) demonstrated a substantially higher percentage of free radical scavenging activity with an IC 50 of 4.65. Vf is regarded as a medication that has both anti-inflammatory and antioxidant properties.